Chayan Kumar Saha

Postdoctoral researcher · Department for Medical Biochemistry and Microbiology · Uppsala University · Sweden

Hi and welcome!

I am a Bioinformatician broadly interested in the ever-evolving dynamics of protein interactions. My goal is to apply my research and bioinformatics skills in the field of medicine and health. Currently, I am privileged to be a Postdoctoral Researcher at Uppsala University, supported by an International Postdoc Grant from the Swedish Research Council (Vetenskapsrådet).

Thank you for your interest, and I look forward to potential collaborations and meaningful connections in the future.


Experience

Postdoctoral researcher

Uppsala University, Uppsala, Sweden

- Project lead
- Develop bioinformatics tool

January 2024 – Present

Bioinformatician

SAGA Diagnostics AB, Lund, Sweden

- Research and development
- NGS data analyses
- Pipeline development

October 2023 – December 2023

Software Developer and Bioinformatician

Bionamic AB, Lund, Sweden

- Building data analyses tool
- Web development

August 2022 – October 2023

Post-doctoral Researcher

Department of Experimental Medical Science, Lund University, Sweden

- Server setup for web tools
- Biological data analyses

May 2022 – August 2022

Doctoral Researcher

Department of Molecular Biology, Umeå University, Sweden

- Phylogenetic analyses of protein families
- Bioinformatics tool and webtool development
- Sequence data anaylses from public database
- Studying Toxin-Antitoxin Systems

April 2018 – March 2022

Project Assistant

Department of Molecular Biology, Umeå University, Sweden

- Sequence analyses such as multiple sequence alignment, phylogenetic analyses, Hidden Markov Models
- Analyses of CLIP-like NGS data

October 2017 – March 2018

Part-time Project Assistant

Department of Biology, Lund University, Sweden

- Analyses of RNA-seq data
- Gene prediction
- Orthology detection

December 2016 – May 2017

Oncology Associate

Sanofi Bangladesh Limited, Dhaka, Bangladesh

- Conduct and monitor local and international clinical studies
- Achieve sales objective

February 2015 – August 2016

Associate-Scientific Services

Roche Bangladesh Limited, Dhaka, Bangladesh

- Organize scientific seminar on cancer management in Bangladesh
- Achieve sales objective

June 2013 – February 2015

Education

Umeå University, Sweden

PhD in Molecular Biology (Speciality: Bioinformatics), Department of Molecular Biology
Topic: Bioinformatics, evolution and revolution in our understanding of toxin-antitoxin systems.
2018 - 2022

Lund University, Sweden

MSc in Bioinformatics, Department of Biology
Thesis: Finding candidate genes underlying early flowering barley mat-e mutants
2016 - 2017

Shahjalal University of Science and Technology, Bangladesh

MSc in Genetic Engineering and Biotechnology
Thesis: F, G and M proteins pertain with evolution and adaptive mechanism of Nipah and Hendra virus
2012 – 2014

Shahjalal University of Science and Technology, Bangladesh

BSc in Genetic Engineering and Biotechnology
Undergraduate Project: In silico epitope identification and characterization for human vaccine against Nipah and Hendra viruses
2007 - 2011

Skills

Bioinformatics Analyses
  • Practical experience on NGS data analyses:

    - Variant calling
    - Gene prediction and annotation
    - Differential gene expression
    - Differential binding analyses
    - Orthology analyses

  • Experienced in sequence analyses:

    - Multiple sequence alignment
    - Phylogenetic analyses
    - Hidden Markov Models

  • Tool and webtool development
  • Version control, database management systems
  • Molecular docking simulation

Programming Languages
  • Python programming language
  • Bash command language
  • R
  • SQL, MySQL
  • Web Programming (JavaScript, CSS, HTML)

Graphics designing
  • Adobe Photoshop
  • Adobe Illustrator

Publications

For reading my doctoral thesis click here.

For citations and H index click here, and for peer review summary click here.

Peer-reviewed original articles: 9
Research review articles: 1

References and Pubmed links:

- Genetic determinants of SARS‐CoV‐2 and the clinical outcome of COVID‐19 in Southern Bangladesh.
Hasan MM, Saha CK, Hamidullah Mehedi HM, Chakma K, Salauddin A, Hossain MS, Sharmen F, Rafiqul Islam SM, Tanni AA, Yasmin F, Akash AS, Hossain ME, Miah M, Biswas SK, Sultana N, Mannan A. Immun Inflamm Dis. 2024 Feb 6;12(2):e1171. doi: 10.1002/iid3.1171.

- The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.
Ernits K*, Saha CK*, Brodiazhenko T, Chouhan B, Shenoy A, Buttress JA, Duque-Pedraza JJ, Bojar V, Nakamoto JA, Kurata T, Egorov AA, Shyrokova L, Johansson MJO, Mets T, Rustamova A, Džigurski J, Tenson T, Garcia-Pino A, Strahl H, Elofsson A, Hauryliuk V, Atkinson GC. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305393120. (*equal contribution)

- Context-based sensing of orthosomycin antibiotics by the translating ribosome.
Mangano K, Marks J, Klepacki D, Saha CK, Atkinson GC, Vázquez-Laslop N, Mankin AS. Nat Chem Biol. 2022 Nov;18(11):1277-1286.

- Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
Mohamad M, Nicholson D, Saha CK, Hauryliuk V, Edwards TA, Atkinson GC, Ranson NA, O'Neill AJ. Nucleic Acids Res. 2022 Feb 28;50(4):2128-2142.

- A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains.
Kurata T*, Saha CK*, Buttress JA, Mets T, Brodiazhenko T, Turnbull KJ, Awoyomi OF, Oliveira SRA, Jimmy S, Ernits K, Delannoy M, Persson K, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2102212119. (*equal contribution)

- FlaGs and webFlaGs: discovering novel biology through the analysis of gene neighbourhood conservation
Saha CK, Pires RS, Brolin H, Delannoy M, Atkinson GC . Bioinformatics. 2021 Jun 9;37(9):1312-1314.

- A holin/peptidoglycan hydrolase‐dependent protein secretion system.
Palmer T, Finney A , Saha CK, Atkinson GC , Sargent F . Molecular Microbiology. 2021 Mar;115(3):345-355.

- A widespread toxin-antitoxin system exploiting growth control via alarmone signaling.
Jimmy S*, Saha CK*, Kurata T*, Stavropoulos C, Oliveira SRA, Koh A, Cepauskas A, Takada H, Rejman D, Tenson T, Strahl H, Garcia-Pino A, Hauryliuk V, Atkinson GC . Proc Natl Acad Sci U S A. 2020 May 12;117(19):10500-10510. (*equal contribution)

- ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life.
Murina V, Kasari M, Takada H, Hinnu M, Saha CK, Grimshaw JW, Seki T, Reith M, Putrinš M, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. J Mol Biol . 2019 Aug 23;431(18):3568-3590.

- In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses.
Saha CK, Mahbub Hasan M, Saddam Hossain M, Asraful Jahan M, Azad AK . Asian Pac J Trop Med. 2017 Jun;10(6):529-538.


Invited research talk

2021 York Microbiology Symposium, University of York, UK

2019 UCMR DAY, Bergasalen, Umeå University Hospital, Sweden

2018 ppGpp-mediated stress response meeting, Tartu, Estonia



Poster

2021 UCMR DAY, Digital Conference

2021 Virtual Conference on Prokaryotic Small Proteins.

2020 UCMR DAY, Aula Nordica, Umeå University, Sweden

2019 8th National Infection Biology/Microbiology Meeting, Aronsborg, Sweden

2018 UCMR DAY, Major and Minor Groove, Building 6L, NUS, Sweden


Doctoral studies course offered from Umeå University

2020 Introduction to doctoral studies

2020 Research methodology and philosophy of science

2020 Research ethics


External course for doctoral student

2020 Visualize Your Science (Online)

2019 Workshop on Phylogenomics, Ceský Krumlov, Czech Republic

2018 English Writing Workshop, Accent Språkservice AB, Gothenburg, Sweden

2017 ChiP-seq data analyses, Science for Life Laboratory, Stockholm, Sweden

2017 Field-omics and remote sensing analysis of ‘-omics’ and phenotypic data in field trials and controlled environments, Swedish University of Agricultural Sciences (SLU), Alnarp, Sweden


Community Affiliation

- President, ISCB-RSG Sweden Umeå Branch

- Trainer (Bioinformatics), ISCB-RSG Bangladesh (Youtube Link of training session in Bangla)


Scholarship & Award